General Information


DRAVP ID  DRAVPe01450

Peptide Name   G154-177[B176A]

Sequence  KPPSKPNNDFHFEVFNFVPBSIAG

Sequence Length  24

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  RSV

Assay  NMR

Activity 

  • [Ref.11487583]Respiratory syncytial virus(RSV):inhibition of the cytopathic effect of RSV in HEp-2 cells(IC50=6 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01450

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  The 'B' at position 20 is S-acetamidomethyl cysteine.

Stereochemistry  L



Physicochemical Information


Formula  C122H172N30O32

Absent amino acids  CLMQRTWY

Common amino acids  FP

Mass  2703.56

Pl  6.75

Basic residues  3

Acidic residues  2

Hydrophobic residues  8

Net charge  1

Boman Index  -3034

Hydrophobicity  -45.83

Aliphatic Index  44.58

Half Life 

  •     Mammalian:1.3 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  6



Literature Information


Literature 1

Title   Antiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein.

Pubmed ID   11487583

Reference   J Biol Chem. 2001 Oct 19;276(42):38988-94.

Author   Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. 

DOI   10.1074/jbc.M106288200