General Information

General Information

DRAVP ID DRAVPe01463

Peptide Name P1

Sequence DTRACDVIALLCHLNT

Sequence Length 16

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism WNV,DENV

Assay RT-QPCR

Activity

[Ref.17151121]west nile virus(WNV):inhibition of virus infection in Vero cells(P1 significantly inhibited WNV infectivity at a concentration of 1 mM,IC50=67.0 ± 0.1 μM);
Dengue virus serotype 2:inhibition of virus infection in Vero cells(99.3±0.7% inhibition at 200 μM)

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.17151121]No cytotoxicity against Vero cells up to 500μM.

Binding Target E proteins

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01463

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C73H124N22O24S2

Absent amino acids EFGKMPQSWY

Common amino acids L

Mass 1758.04

Pl 5.21

Basic residues 2

Acidic residues 2

Hydrophobic residues 7

Net charge 0

Boman Index -1890

Hydrophobicity 56.88

Aliphatic Index 128.13

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 125

Absorbance 280nm 8.33

Polar residues 5

Literature Information

Literature 1

Title Antiviral peptides targeting the west nile virus envelope protein.

Pubmed ID 17151121

Reference J Virol. 2007 Feb;81(4):2047-55.

Author Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E.

DOI 10.1128/JVI.01840-06