General Information

General Information

DRAVP ID DRAVPe01463

Peptide Name P1

Sequence DTRACDVIALLCHLNT

Sequence Length 16

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism WNV,DENV

Assay RT-QPCR

Activity

[Ref.17151121]west nile virus(WNV):inhibition of virus infection in Vero cells(P1 significantly inhibited WNV infectivity at a concentration of 1 mM,IC50=67.0 ± 0.1 μM);
Dengue virus serotype 2:inhibition of virus infection in Vero cells(99.3±0.7% inhibition at 200 μM)

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.17151121]No cytotoxicity against Vero cells up to 500μM.

Binding Target E proteins

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01463

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C73H124N22O24S2

Absent amino acids EFGKMPQSWY

Common amino acids L

Mass 1758.04

Pl 5.21

Basic residues 2

Acidic residues 2

Hydrophobic residues 7

Net charge 0

Boman Index -1890

Hydrophobicity 56.88

Aliphatic Index 128.13

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 125

Absorbance 280nm 8.33

Polar residues 5

Literature Information

Literature 1

Title Antiviral peptides targeting the west nile virus envelope protein.

Pubmed ID 17151121

Reference J Virol. 2007 Feb;81(4):2047-55.

Author Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E.

DOI 10.1128/JVI.01840-06