General Information


DRAVP ID  DRAVPe01463

Peptide Name   P1

Sequence  DTRACDVIALLCHLNT

Sequence Length  16

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  WNV,DENV

Assay  RT-QPCR

Activity 

  • [Ref.17151121]west nile virus(WNV):inhibition of virus infection in Vero cells(P1 significantly inhibited WNV infectivity at a concentration of 1 mM,IC50=67.0 ± 0.1 μM);
  • Dengue virus serotype 2:inhibition of virus infection in Vero cells(99.3±0.7% inhibition at 200 μM)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.17151121]No cytotoxicity against Vero cells up to 500μM.

Binding Target  E proteins

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01463

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C73H124N22O24S2

Absent amino acids  EFGKMPQSWY

Common amino acids  L

Mass  1758.04

Pl  5.21

Basic residues  2

Acidic residues  2

Hydrophobic residues  7

Net charge  0

Boman Index  -1890

Hydrophobicity  56.88

Aliphatic Index  128.13

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  125

Absorbance 280nm  8.33

Polar residues  5



Literature Information


Literature 1

Title   Antiviral peptides targeting the west nile virus envelope protein.

Pubmed ID   17151121

Reference   J Virol. 2007 Feb;81(4):2047-55. 

Author   Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E.

DOI   10.1128/JVI.01840-06