General Information


DRAVP ID  DRAVPe01467

Peptide Name   P11

Sequence  CDVIALLCHLNTPSFNTTHYRESWY

Sequence Length  25

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  WNV

Assay  RT-QPCR

Activity 

  • [Ref.17151121]west nile virus(WNV):inhibition of virus infection in Vero cells(P10 significantly inhibited WNV infectivity).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  E proteins

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01467

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C134H195N35O39S2

Absent amino acids  GKMQ

Common amino acids  LT

Mass  2984.35

Pl  5.99

Basic residues  3

Acidic residues  2

Hydrophobic residues  8

Net charge  1

Boman Index  -3444

Hydrophobicity  -16

Aliphatic Index  78

Half Life 

  •     Mammalian:1.2 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  8605

Absorbance 280nm  358.54

Polar residues  11



Literature Information


Literature 1

Title   Antiviral peptides targeting the west nile virus envelope protein.

Pubmed ID   17151121

Reference   J Virol. 2007 Feb;81(4):2047-55. 

Author   Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E.

DOI   10.1128/JVI.01840-06