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General Information
DRAVP ID DRAVPe01482
Peptide Name Peptide 75(710-725)[Δ12-16]
Sequence VSFAIKWEYVL
Sequence Length 11
UniProt ID P26663
Source Synthetic construct(derived from HCV envelope protein)
Activity Information
Target Organism HCV
Assay Luciferase assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target envelope protein
Mechanism The peptide inhibits a post-binding step in HCV entry.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01482
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C68H99N13O16
Absent amino acids CDGHMNPQRT
Common amino acids V
Mass 1354.61
Pl 5.97
Basic residues 1
Acidic residues 1
Hydrophobic residues 7
Net charge 0
Boman Index 914
Hydrophobicity 99.09
Aliphatic Index 132.73
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 699
Polar residues 2
Literature Information
Literature 1
Title A peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry.
Pubmed ID 20156485
Reference Antiviral Res. 2010 May;86(2):172-9.
Author Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.