General Information


DRAVP ID  DRAVPe01487

Peptide Name   GBVA1(1-18)

Sequence  LLDCWVRLGRYLLRRLKT

Sequence Length  18

UniProt ID  Q69422 

Source  Synthetic construct(derived from GBVA non-structutal protein 5A)



Activity Information


Target Organism  HCV

Assay  qRT-PCR assay

Activity 

  • [Ref.23175359]hepatitis C virus(Jc1-Luc HCVcc):inhibition of virus entry in Huh7.5.1 cells(IC50=10 μM,88% inhibition at 20 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  The peptide inhibits virus entry.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01487

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C104H176N32O23S

Absent amino acids  AEFHIMNPQS

Common amino acids  L

Mass  2274.8

Pl  10.85

Basic residues  5

Acidic residues  1

Hydrophobic residues  8

Net charge  4

Boman Index  -3855

Hydrophobicity  4.44

Aliphatic Index  146.11

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  6990

Absorbance 280nm  411.18

Polar residues  4



Literature Information


Literature 1

Title   Screening and rational design of hepatitis C virus entry inhibitory peptides derived from GB virus A NS5A.

Pubmed ID   23175359

Reference   J Virol. 2013 Feb;87(3):1649-57.

Author   Liu X, Huang Y, Cheng M, Pan L, Si Y, Li G, Niu Y, Zhao L, Zhao J, Li X, Chen Y, Yang W.

DOI   10.1128/JVI.02201-12