General Information


DRAVP ID  DRAVPe01519

Peptide Name   E6ap18

Sequence  IPESSELTLQELLGEERR

Sequence Length  18

UniProt ID  No entry found

Source  Synthetic construct(derived from E6-associated protein (E6AP))



Activity Information


Target Organism  HPV

Assay  CD spectroscopy

Activity 

  • [Ref.15182185]Human papillomavirus(HPV):inhibition of E6-E6ap interaction(IC50=10.5±1.4 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  E6 protein

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01519

Linear/Cyclic  Linear

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C89H151N25O33

Absent amino acids  ACDFHKMNVWY

Common amino acids  E

Mass  2099.33

Pl  4.33

Basic residues  2

Acidic residues  5

Hydrophobic residues  5

Net charge  -3

Boman Index  -5326

Hydrophobicity  -81.11

Aliphatic Index  108.33

Half Life 

  •     Mammalian:20 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  4



Literature Information


Literature 1

Title   Design and characterization of helical peptides that inhibit the E6 protein of papillomavirus.

Pubmed ID   15182185

Reference   Biochemistry. 2004 Jun 15;43(23):7421-31. 

Author   Liu Y, Liu Z, Androphy E, Chen J, Baleja JD.

DOI   10.1021/bi049552a