DRAVP ID  DRAVPe01526

Peptide Name   RatNP-1

Sequence  VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR

Sequence Length  32

UniProt ID  Q62716 

Taxon ID  None

Source  Rattus norvegicus

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV

Assay 

Activity 

• [Ref.12543649]HSV-2:inhibition of HSV-2 infection in Vero cells(98.7%±0.7% inhibition at 25 μg/ ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.12543649]No cytotoxic effect on CaSki cells was observed at the concentration of 25 or 100 μg/ml.

Binding Target  membrane

Mechanism  NP-1 inactivates HSV and prevents viral entry and cell-to-cell spread. NP-1 blocks fusion events important in HSV acquisition and transmission.

PDB ID  None

Predicted Structure Download  DRAVPe01526

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.

Stereochemistry  L

Literature 1

Title   NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2. 

Pubmed ID   12543649

Reference   Antimicrob Agents Chemother. 2003 Feb;47(2):494-500.

Author   Sinha S, Cheshenko N, Lehrer RI, Herold BC.

DOI   10.1128/AAC.47.2.494-500.2003