General Information
DRAVP ID DRAVPe01526
Peptide Name RatNP-1
Sequence VTCYCRRTRCGFRERLSGACGYRGRIYRLCCR
Sequence Length 32
UniProt ID Q62716
Source Rattus norvegicus
Activity Information
Target Organism HSV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism NP-1 inactivates HSV and prevents viral entry and cell-to-cell spread. NP-1 blocks fusion events important in HSV acquisition and transmission.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01526
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification Disulfide bonds between Cys3 and Cys31,Cys5 and Cys20,Cys10 and Cys30.
Stereochemistry L
Physicochemical Information
Formula C158H261N59O41S6
Absent amino acids DHKMNPQW
Common amino acids R
Mass 3835.54
Pl 9.99
Basic residues 9
Acidic residues 1
Hydrophobic residues 6
Net charge 8
Boman Index -11502
Hydrophobicity -49.38
Aliphatic Index 48.75
Half Life
Extinction Coefficient cystines 4845
Absorbance 280nm 156.29
Polar residues 16
Literature Information
Literature 1
Title NP-1, a rabbit alpha-defensin, prevents the entry and intercellular spread of herpes simplex virus type 2.
Pubmed ID 12543649
Reference Antimicrob Agents Chemother. 2003 Feb;47(2):494-500.
Author Sinha S, Cheshenko N, Lehrer RI, Herold BC.