General Information

General Information

DRAVP ID DRAVPe01546

Peptide Name BMAP-18P9

Sequence GRFKRFRKPFKKLFKKIS

Sequence Length 18

UniProt ID No entry found

Taxon ID None

Source Synthetic construct(derived from BMAP-27)

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HIV

Assay

Activity

[Ref.18591279]HIV-1IIIB:inhibition the cytopathic effect of HIV in CEM-SS cells(EC50=3.20 μM).(EC50:50% effective concentration for inhibition of virus replication)

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.18591279]CEM-SS cells:TC50=18.9 μM.(TC50:the concentration that reduced cell viability by 50%)

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01546

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C112H183N33O20

Absent amino acids ACDEHMNQTVWY

Common amino acids K

Mass 2311.89

Pl 12.32

Basic residues 9

Acidic residues 0

Hydrophobic residues 6

Net charge 9

Boman Index -5876

Hydrophobicity -112.22

Aliphatic Index 43.33

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins.

Pubmed ID 18591279

Reference Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.

Author Wang G, Watson KM, Buckheit RW Jr.

DOI 10.1128/AAC.00452-08