General Information


DRAVP ID  DRAVPe01547

Peptide Name   BMAP-18X6X10

Sequence  GRFKRXRKKXKKLFKKIS

Sequence Length  18

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct(derived from BMAP-27)

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HIV

Assay 

Activity 

  • [Ref.18591279]HIV-1IIIB:inhibition the cytopathic effect of HIV in CEM-SS cells(EC50=0.68 μM).(EC50:50% effective concentration for inhibition of virus replication)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.18591279]CEM-SS cells:TC50=10.2 μM.(TC50:the concentration that reduced cell viability by 50%)

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01547

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  The 'X' at position 6 and 10 are phenylglycine

Stereochemistry  L



Physicochemical Information


Formula  C95H166N32O16

Absent amino acids  ACDEHMNPQTVWY

Common amino acids  K

Mass  2271.26

Pl  12.32

Basic residues  10

Acidic residues  0

Hydrophobic residues  4

Net charge  10

Boman Index  -7027

Hydrophobicity  -156.11

Aliphatic Index  43.33

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins.

Pubmed ID   18591279

Reference   Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40. 

Author   Wang G, Watson KM, Buckheit RW Jr. 

DOI   10.1128/AAC.00452-08