General Information

General Information

DRAVP ID DRAVPe01548

Peptide Name BMAP-18I6L10

Sequence GRFKRIRKKLKKLFKKIS

Sequence Length 18

UniProt ID No entry found

Source Synthetic construct(derived from BMAP-27)

Activity Information

Target Organism HIV

Assay

Activity

[Ref.18591279]HIV-1IIIB:inhibition the cytopathic effect of HIV in CEM-SS cells(EC50>44.0 μM).(EC50:50% effective concentration for inhibition of virus replication)

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.18591279]CEM-SS cells:TC50=2.79 μM.(TC50:the concentration that reduced cell viability by 50%)

Binding Target Not found

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download DRAVPe01548

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C107H192N34O20

Absent amino acids ACDEHMNPQTVWY

Common amino acids K

Mass 2274.92

Pl 12.32

Basic residues 10

Acidic residues 0

Hydrophobic residues 6

Net charge 10

Boman Index -6043

Hydrophobicity -110

Aliphatic Index 86.67

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Literature Information

Literature 1

Title Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins.

Pubmed ID 18591279

Reference Antimicrob Agents Chemother. 2008 Sep;52(9):3438-40.

Author Wang G, Watson KM, Buckheit RW Jr.

DOI 10.1128/AAC.00452-08