DRAVP ID  DRAVPe01563

Peptide Name   RC-116

Sequence  RYICRCICGRGICRCICG

Sequence Length  18

UniProt ID  No entry found

Source  Synthetic construct

Other Link  DRAVPa0165

Target Organism  HIV

Assay 

Activity 

• [Ref.15588337]HIV-1 92US714:inhibition of virus replication in JC53-BL cells(IC50=9.5 µg/ml);
• HIV-1 93US151:inhibition of virus replication in JC53-BL cells(IC50=1.3 µg/ml);
• HIV-1 92HT593:inhibition of virus replication in JC53-BL cells(IC50=3.7 µg/ml);
• HIV-1 92US727:inhibition of virus replication in JC53-BL cells(IC50=4.6µg/ml);
• HIV-1 5148-1382:inhibition of virus replication in JC53-BL cells(IC50=5.2 µg/ml);
• HIV-1 5157-1326:inhibition of virus replication in JC53-BL cells(IC50=4.8 µg/ml);
• HIV-1 5157-35097:inhibition of virus replication in JC53-BL cells(IC50=5.2 µg/ml);
• HIV-1 193317:inhibition of virus replication in JC53-BL cells(IC50=7.1 µg/ml);
• HIV-1 196554:inhibition of virus replication in JC53-BL cells(IC50=2.4 µg/ml);
• HIV-1 196531:inhibition of virus replication in JC53-BL cells(IC50=7.8 µg/ml);
• HIV-1 92UG037:inhibition of virus replication in JC53-BL cells(IC50=3.1 µg/ml);
• HIV-1 192431:inhibition of virus replication in JC53-BL cells(IC50=2.4 µg/ml);
• HIV-1 193358:inhibition of virus replication in JC53-BL cells(IC50=7.8 µg/ml);
• HIV-1 98CN009:inhibition of virus replication in JC53-BL cells(IC50>10 µg/ml);
• HIV-1 98TZ017:inhibition of virus replication in JC53-BL cells(IC50>10 µg/ml);
• HIV-1 93UG053:inhibition of virus replication in JC53-BL cells(IC50=6.6 µg/ml);
• HIV-1 92UG005:inhibition of virus replication in JC53-BL cells(IC50=5.2 µg/ml);
• HIV-1 94UG114:inhibition of virus replication in JC53-BL cells(IC50=4.2 µg/ml);
• HIV-1 HM14:inhibition of virus replication in JC53-BL cells(IC50=3.3 µg/ml);
• HIV-1 93TH060:inhibition of virus replication in JC53-BL cells(IC50=6.5 µg/ml);
• HIV-1 HM16:inhibition of virus replication in JC53-BL cells(IC50=2.9 µg/ml);
• HIV-1 RU132:inhibition of virus replication in JC53-BL cells(IC50=4.9 µg/ml);
• HIV-1 RU570:inhibition of virus replication in JC53-BL cells(IC50=9.6 µg/ml);
• HIV-1 92BR023:inhibition of virus replication in JC53-BL cells(IC50=2.9 µg/ml);
• HIV-1 92RW009:inhibition of virus replication in JC53-BL cells(IC50=7.8 µg/ml);
• HIV-1 92RW024:inhibition of virus replication in JC53-BL cells(IC50=6.6 µg/ml);
• HIV-1 93UG059:inhibition of virus replication in JC53-BL cells(IC50=5.7 µg/ml).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  gp120,CD4

Mechanism  The peptide binds to gp120 and CD4, thereby inhibiting HIV entry.

PDB ID  None

Predicted Structure Download  DRAVPe01563

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  Disulfide bonds between Cys4 and Cys17,Cys6 and Cys15,Cys8 and Cys13.

Stereochemistry  L

Literature 1

Title   RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates.

Pubmed ID   15588337

Reference   AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65.

Author   Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. 

DOI   10.1089/aid.2004.20.1157