General Information


DRAVP ID  DRAVPe01568

Peptide Name   Apelin-15

Sequence  RRQRPRLSHKGPMPF

Sequence Length  15

UniProt ID  Q9TUI9 

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  Reverse transcriptase assay

Activity 

  • [Ref.11090199]HIV-1:inhibition of HIV-1 infection in CD4 APJ cells(IC50=12μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  APJ receptor

Mechanism  APJ receptor could help HIV virus enter the target cells. The peptide can bind with APJ receptor and block virus entry, thus inhibiting virus infection.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01568

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C81H135N31O18S

Absent amino acids  ACDEINTVWY

Common amino acids  R

Mass  1863.22

Pl  12.48

Basic residues  6

Acidic residues  0

Hydrophobic residues  2

Net charge  6

Boman Index  -6764

Hydrophobicity  -174

Aliphatic Index  26

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2



Literature Information


Literature 1

Title   Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry. 

Pubmed ID   11090199

Reference   J Virol. 2000 Dec;74(24):11972-6.

Author   Cayabyab M, Hinuma S, Farzan M, Choe H, Fukusumi S, Kitada C, Nishizawa N, Hosoya M, Nishimura O, Messele T, Pollakis G, Goudsmit J, Fujino M, Sodroski J.

DOI   10.1128/jvi.74.24.11972-11976.2000