General Information


DRAVP ID  DRAVPe01574

Peptide Name   TAT(48-57)[G1R]

Sequence  RRKKRRQRRR

Sequence Length  10

UniProt ID  P04610 

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  infection inhibition assay

Activity 

  • [Ref.22319541]HIV-1 IIIB:inhibition of virus infection in P4-R5 MAGI cells(EC50=0.065 mg/mL).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01574

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C59H118N34O12

Absent amino acids  ACDEFGHILMNPSTVWY

Common amino acids  R

Mass  1495.81

Pl  12.78

Basic residues  9

Acidic residues  0

Hydrophobic residues  0

Net charge  9

Boman Index  -12108

Hydrophobicity  -428

Aliphatic Index  0

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat.

Pubmed ID   22319541

Reference   Int J Pept. 2012;2012:349427.

Author   Keogan S, Passic S, Krebs FC.

DOI   10.1155/2012/349427