General Information


DRAVP ID  DRAVPe01577

Peptide Name   R-10

Sequence  RRRRRRRRRR

Sequence Length  10

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  infection inhibition assay

Activity 

  • [Ref.22319541]HIV-1 IIIB:inhibition of virus infection in P4-R5 MAGI cells(EC50=0.014 mg/mL).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  No machanism information found in the reference(s) presented in this entry



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01577

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C60H122N40O11

Absent amino acids  ACDEFGHIKLMNPQSTVWY

Common amino acids  R

Mass  1579.89

Pl  12.95

Basic residues  10

Acidic residues  0

Hydrophobic residues  0

Net charge  10

Boman Index  -14920

Hydrophobicity  -450

Aliphatic Index  0

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Infection by CXCR4-Tropic Human Immunodeficiency Virus Type 1 Is Inhibited by the Cationic Cell-Penetrating Peptide Derived from HIV-1 Tat.

Pubmed ID   22319541

Reference   Int J Pept. 2012;2012:349427.

Author   Keogan S, Passic S, Krebs FC.

DOI   10.1155/2012/349427