To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01607
Peptide Name Octa 1
Sequence RRWYRWW
Sequence Length 7
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HSV
Assay plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism The anti-HSV1 activity of apoEdp involves inhibition of virus particle attachment to cells, with this likely being related to the derivation of this peptide from the apoE HSPG/LDLR binding region.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01607
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C60H77N19O9
Absent amino acids ACDEFGHIKLMNPQSTV
Common amino acids RW
Mass 1208.39
Pl 11.71
Basic residues 3
Acidic residues 0
Hydrophobic residues 3
Net charge 3
Boman Index -3791
Hydrophobicity -250
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 17990
Absorbance 280nm 2998.33
Polar residues 1
Literature Information
Literature 1
Title Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity.
Pubmed ID 17681018
Reference FEBS J. 2007 Sep;274(17):4511-25.
Author Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.