General Information


DRAVP ID  DRAVPe01608

Peptide Name   MU89 (Octa 1 dp)

Sequence  RRWYRWWRRRWYRWWR

Sequence Length  16

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HSV

Assay  plaque reduction assay

Activity 

  • [Ref.17681018]HSV-1:inhibition of virus infection in NP-2/CD4/CCR5 cells(IC50=8.3 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  The anti-HSV1 activity of apoEdp involves inhibition of virus particle attachment to cells, with this likely being related to the derivation of this peptide from the apoE HSPG/LDLR binding region.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01608

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C132H176N46O19

Absent amino acids  ACDEFGHIKLMNPQSTV

Common amino acids  R

Mass  2711.15

Pl  12.22

Basic residues  8

Acidic residues  0

Hydrophobic residues  6

Net charge  8

Boman Index  -10566

Hydrophobicity  -275

Aliphatic Index  0

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  35980

Absorbance 280nm  2398.67

Polar residues  2



Literature Information


Literature 1

Title   Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity.

Pubmed ID   17681018

Reference   FEBS J. 2007 Sep;274(17):4511-25.

Author   Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB.

DOI   10.1111/j.1742-4658.2007.05981.x