General Information


DRAVP ID  DRAVPe01611

Peptide Name   Deca 1

Sequence  YRWWRWARRW

Sequence Length  10

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HSV

Assay  plaque reduction assay

Activity 

  • [Ref.17681018]HSV-1:inhibition of virus infection in NP-2/CD4/CCR5 cells(IC50>20 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  The anti-HSV1 activity of apoEdp involves inhibition of virus particle attachment to cells, with this likely being related to the derivation of this peptide from the apoE HSPG/LDLR binding region.



Structure Information


PDB ID  None

Predicted Structure Download  DRAVPe01611

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C80H104N26O12

Absent amino acids  CDEFGHIKLMNPQSTV

Common amino acids  RW

Mass  1621.87

Pl  12

Basic residues  4

Acidic residues  0

Hydrophobic residues  5

Net charge  4

Boman Index  -4869

Hydrophobicity  -211

Aliphatic Index  10

Half Life 

  •     Mammalian:2.8 hour
  •     Yeast:10 min
  •     E.coli:2 min

Extinction Coefficient cystines  23490

Absorbance 280nm  2610

Polar residues  1



Literature Information


Literature 1

Title   Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity.

Pubmed ID   17681018

Reference   FEBS J. 2007 Sep;274(17):4511-25.

Author   Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB.

DOI   10.1111/j.1742-4658.2007.05981.x