To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01611
Peptide Name Deca 1
Sequence YRWWRWARRW
Sequence Length 10
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HSV
Assay plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism The anti-HSV1 activity of apoEdp involves inhibition of virus particle attachment to cells, with this likely being related to the derivation of this peptide from the apoE HSPG/LDLR binding region.
Structure Information
PDB ID None
Predicted Structure Download DRAVPe01611
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C80H104N26O12
Absent amino acids CDEFGHIKLMNPQSTV
Common amino acids RW
Mass 1621.87
Pl 12
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index -4869
Hydrophobicity -211
Aliphatic Index 10
Half Life
Extinction Coefficient cystines 23490
Absorbance 280nm 2610
Polar residues 1
Literature Information
Literature 1
Title Apolipoprotein E-derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity.
Pubmed ID 17681018
Reference FEBS J. 2007 Sep;274(17):4511-25.
Author Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA, Dobson CB.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.