General Information


DRAVP ID  DRAVPe01625

Peptide Name   None

Sequence  HAKFWW

Sequence Length  6

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  integrase assay

Activity 

  • [Ref.8524782]HIV-1:inhibition of integrase-mediated 3'-processing and integration(IC50=30 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  integrase

Mechanism  The peptide may inhibit integrase-mediated 3'-processing and integration, which is useful for inhibiting virus replication.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C46H55N11O7

Absent amino acids  CDEGILMNPQRSTVY

Common amino acids  W

Mass  874.01

Pl  8.76

Basic residues  2

Acidic residues  0

Hydrophobic residues  4

Net charge  2

Boman Index  -76

Hydrophobicity  -71.67

Aliphatic Index  16.67

Half Life 

  •     Mammalian:3.5 hour
  •     Yeast:10 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  11000

Absorbance 280nm  2200

Polar residues  0



Literature Information


Literature 1

Title   Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library.

Pubmed ID   8524782

Reference   Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11456-60.

Author   Puras Lutzke RA, Eppens NA, Weber PA, Houghten RA, Plasterk RH.

DOI   10.1073/pnas.92.25.11456