DRAVP ID  DRAVPe01627

Peptide Name   P1(ACE2 (4-13))

Sequence  EEQAKTFLDK

Sequence Length  10

UniProt ID  Q9BYF1 

Source  Synthetic construct(derived from angiotensin-converting enzyme 2)

Target Organism  SARS-CoV

Assay  Pseudovirus infection assay

Activity 

• [Ref.16510163]SARS-CoV:inhibition of pseudovirus infection in HeLa cells(25% inhibition at 100 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  spike glycoprotein

Mechanism  Virus entry into cells is mediated through interactions between spike (S) glycoprotein and angiotensin-converting enzyme 2 (ACE2), peptide derived from ACE2 could bind with spike glycoprotein and inhibits virus entry.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor.

Pubmed ID   16510163

Reference   Virology. 2006 Jun 20;350(1):15-25.

Author   Han DP, Penn-Nicholson A, Cho MW.

DOI   10.1016/j.virol.2006.01.029