General Information
DRAVP ID DRAVPe01629
Peptide Name P3(ACE2 (15-23))
Sequence NHEAEDLFY
Sequence Length 9
UniProt ID Q9BYF1
Taxon ID None
Source Synthetic construct(derived from angiotensin-converting enzyme 2)
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism SARS-CoV
Assay Pseudovirus infection assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target spike glycoprotein
Mechanism Virus entry into cells is mediated through interactions between spike (S) glycoprotein and angiotensin-converting enzyme 2 (ACE2), peptide derived from ACE2 could bind with spike glycoprotein and inhibits virus entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C51H68N12O18
Absent amino acids CGIKMPQRSTVW
Common amino acids E
Mass 1137.17
Pl 4.13
Basic residues 1
Acidic residues 3
Hydrophobic residues 3
Net charge -2
Boman Index -2407
Hydrophobicity -112.22
Aliphatic Index 54.44
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 186.25
Polar residues 2
Literature Information
Literature 1
Title Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor.
Pubmed ID 16510163
Reference Virology. 2006 Jun 20;350(1):15-25.
Author Han DP, Penn-Nicholson A, Cho MW.