General Information
DRAVP ID DRAVPe01638
Peptide Name DENV Envelope glycoprotein (98-109)
Sequence DRGWGNGCGLFG
Sequence Length 12
Source Synthetic construct(derived from DENV Envelope glycoprotein)
Activity Information
Target Organism DENV
Assay Focus-forming assay (FFA)
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target E protein
Mechanism The peptide acts as inhibitors by binding to the E protein, suppressing its conformational changes, and preventing its binding to the cellular receptor, thereby inhibiting viral entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C53H75N17O16S
Absent amino acids AEHIKMPQSTVY
Common amino acids G
Mass 1238.34
Pl 5.83
Basic residues 1
Acidic residues 1
Hydrophobic residues 3
Net charge 0
Boman Index -1407
Hydrophobicity -44.17
Aliphatic Index 32.5
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 500
Polar residues 7
Literature Information
Literature 1
Title In vitro analysis of synthetic peptides in blocking the entry of dengue virus.
Pubmed ID 30508603
Reference Virus Res. 2019 Jan 15;260:142-150.
Author John AM, Jittmittraphap A, Chattanadee S, Alwin Prem Anand A, Shenbagarathai R, Leaungwutiwong P.