General Information
DRAVP ID DRAVPe01655
Peptide Name Peptide 4
Sequence GGVLVQPG
Sequence Length 8
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism SARS-CoV-2,HCMV,VZV
Assay Cytopathic effect assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Main protease
Mechanism No machanism information found in the reference(s) presented in this entry
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Pivaloylation
C-terminal Modification Methyl amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C32H55N9O10
Absent amino acids ACDEFHIKMNRSTWY
Common amino acids G
Mass 725.84
Pl 5.52
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 1028
Hydrophobicity 73.75
Aliphatic Index 121.25
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Literature Information
Literature 1
Title Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation.
Pubmed ID 34502335
Reference Int J Mol Sci. 2021 Aug 30;22(17):9427.
Author Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A.