General Information

General Information

DRAVP ID DRAVPe01656

Peptide Name Peptide 5

Sequence GVLVQ

Sequence Length 5

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism SARS-CoV-2,HCMV,VZV

Assay Cytopathic effect assay

Activity

[Ref.34502335]SARS-CoV-2 UC-1074:inhibition of virus activity in Vero cells(EC50≥20 μM);
SARS-CoV-2 UC-1075:inhibition of virus activity in Vero cells(EC50>20 μM);
cytomegalovirus (HCMV) AD-169 Strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>20 µM);
cytomegalovirus (HCMV) Davis strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>100 µM);
varicella-zoster virus (VZV) TK+ VZV Strain OKA:inhibition of virus activity in human embryonic lung (HEL) cells(EC50=59.80 µM);
varicella-zoster virus (VZV) TK-VZV Strain 07–1:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>100 µM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.34502335]Vero cell:CC50=75.0 ±2.2 µM.

Binding Target Main protease

Mechanism No machanism information found in the reference(s) presented in this entry

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Acylation

C-terminal Modification Methyl amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C23H42N6O7

Absent amino acids ACDEFHIKMNPRSTWY

Common amino acids V

Mass 514.62

Pl 5.52

Basic residues 0

Acidic residues 0

Hydrophobic residues 3

Net charge 0

Boman Index 840

Hydrophobicity 166

Aliphatic Index 194

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Literature Information

Literature 1

Title Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation.

Pubmed ID 34502335

Reference Int J Mol Sci. 2021 Aug 30;22(17):9427.

Author Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A.

DOI 10.3390/ijms22179427