DRAVP ID  DRAVPe01657

Peptide Name   Peptide 6

Sequence  GVLV

Sequence Length  4

UniProt ID  No entry found

Source  Synthetic construct

Target Organism  SARS-CoV-2,HCMV,VZV

Assay  Cytopathic effect assay

Activity 

• [Ref.34502335]SARS-CoV-2 UC-1074:inhibition of virus activity in Vero cells(EC50≥20 μM);
• SARS-CoV-2 UC-1075:inhibition of virus activity in Vero cells(EC50>20 μM);
• cytomegalovirus (HCMV) AD-169 Strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>4 µM);
• cytomegalovirus (HCMV) Davis strain:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>20 µM);
• varicella-zoster virus (VZV) TK+ VZV Strain OKA:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>20 µM);
• varicella-zoster virus (VZV) TK-VZV Strain 07–1:inhibition of virus activity in human embryonic lung (HEL) cells(EC50>20 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.34502335]Vero cell:CC50=77.4 ±0.7 µM.

Binding Target  Main protease

Mechanism  No machanism information found in the reference(s) presented in this entry

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acylation

C-terminal Modification  Methyl amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation.

Pubmed ID   34502335

Reference   Int J Mol Sci. 2021 Aug 30;22(17):9427.

Author   Di Micco S, Musella S, Sala M, Scala MC, Andrei G, Snoeck R, Bifulco G, Campiglia P, Fasano A.

DOI   10.3390/ijms22179427