General Information


DRAVP ID  DRAVPe01675

Peptide Name   E1P40-2

Sequence  ELKWESEFWRWTEQLASN

Sequence Length  18

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  Fluorescence resonance energy transfer (FRET) assay

Activity 

  • [Ref.26905802]HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells(IC50>125 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  gp41

Mechanism  The peptide inhibits HIV-1 Env-mediated cell fusion thus inhibits virus infection.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C108H151N27O32

Absent amino acids  CDGHIMPVY

Common amino acids  E

Mass  2339.55

Pl  4.49

Basic residues  2

Acidic residues  4

Hydrophobic residues  7

Net charge  -2

Boman Index  -4764

Hydrophobicity  -123.33

Aliphatic Index  48.89

Half Life 

  •     Mammalian:1 hour
  •     Yeast:30 min
  •     E.coli:>10 hour

Extinction Coefficient cystines  16500

Absorbance 280nm  970.59

Polar residues  4



Literature Information


Literature 1

Title   Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor.

Pubmed ID   26905802

Reference   Biochim Biophys Acta. 2016 Jun;1860(6):1139-48.

Author   Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I.

DOI   10.1016/j.bbagen.2016.02.008