General Information


DRAVP ID  DRAVPe01684

Peptide Name   E1P43-2

Sequence  RWTEQLASNYWILEYLWK

Sequence Length  18

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HIV

Assay  Fluorescence resonance energy transfer (FRET) assay

Activity 

  • [Ref.26905802]HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells(IC50=19.7 ± 9.1 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  gp41

Mechanism  The peptide inhibits HIV-1 Env-mediated cell fusion thus inhibits virus infection.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C116H163N27O29

Absent amino acids  CDFGHMPV

Common amino acids  LW

Mass  2399.73

Pl  6.14

Basic residues  2

Acidic residues  2

Hydrophobic residues  8

Net charge  0

Boman Index  -2404

Hydrophobicity  -63.89

Aliphatic Index  92.22

Half Life 

  •     Mammalian:1 hour
  •     Yeast:2 min
  •     E.coli:2 min

Extinction Coefficient cystines  19480

Absorbance 280nm  1145.88

Polar residues  5



Literature Information


Literature 1

Title   Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor.

Pubmed ID   26905802

Reference   Biochim Biophys Acta. 2016 Jun;1860(6):1139-48.

Author   Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I.

DOI   10.1016/j.bbagen.2016.02.008