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General Information
DRAVP ID DRAVPe01693
Peptide Name E1P46-2
Sequence YWILEYLWKVPFDFWRGV
Sequence Length 18
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism HIV
Assay Fluorescence resonance energy transfer (FRET) assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target gp41
Mechanism The peptide inhibits HIV-1 Env-mediated cell fusion thus inhibits virus infection.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C125H165N25O25
Absent amino acids ACHMNQST
Common amino acids W
Mass 2417.84
Pl 6.07
Basic residues 2
Acidic residues 2
Hydrophobic residues 10
Net charge 0
Boman Index 45
Hydrophobicity 18.89
Aliphatic Index 97.22
Half Life
Extinction Coefficient cystines 19480
Absorbance 280nm 1145.88
Polar residues 3
Literature Information
Literature 1
Title Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor.
Pubmed ID 26905802
Reference Biochim Biophys Acta. 2016 Jun;1860(6):1139-48.
Author Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.