DRAVP ID  DRAVPe01724

Peptide Name   P6(SARS-CoV (1153–1175))

Sequence  GINASVVNIQKEIDRLNEVAKNL

Sequence Length  23

UniProt ID  P59594 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not available

Target Organism  SARS-CoV

Assay  cell fusion inhibition assay

Activity 

• [Ref.18983873]SARS-CoV:inhibition of cell fusion in Hela cells (IC50=1.04 ± 0.22 μM); inhibition of SARS-CoV infection in Vero-E6 cells (IC50=2.28 ± 0.81 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.18983873]No discernable cytotoxicity on HeLa or VeroE6 cells at the concentrations of 25 μM.

Binding Target  membrane

Mechanism  Binding to the HR1 region and blocking the formation of a 6-helix bundle during the fusion step of virus entry, thus inhibiting virus entry.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors.

Pubmed ID   18983873

Reference   Antiviral Res. 2009 Jan;81(1):82-7.

Author   Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK.

DOI   10.1016/j.antiviral.2008.10.001