To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01728
Peptide Name SARS-CoV (770-788)[Y771W]
Sequence MWKTPTLKYFGGFNFSQIL
Sequence Length 19
UniProt ID Q19QX0
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism SARS-CoV
Assay Plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target cell membrane
Mechanism inhibits viral entry through coiled coil interactions.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C111H160N24O26S
Absent amino acids ACDEHRV
Common amino acids F
Mass 2278.7
Pl 9.7
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index -170
Hydrophobicity 4.21
Aliphatic Index 61.58
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 388.33
Polar residues 7
Literature Information
Literature 1
Title Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein.
Pubmed ID 16616792
Reference Virus Res. 2006 Sep;120(1-2):146-55.
Author Sainz B Jr, Mossel EC, Gallaher WR, Wimley WC, Peters CJ, Wilson RB, Garry RF.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.