General Information


DRAVP ID  DRAVPe01739

Peptide Name   SARS-CoV-S (1134-1189)

Sequence  LDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE

Sequence Length  56

UniProt ID  P59594 

Source  Synthetic construct



Activity Information


Target Organism  SARS-CoV, MHV

Assay  Infection inhibition assay

Activity 

  • [Ref.15150417]SARS-CoV: inhibition of SARS-CoV infection in Vero 118 cells (EC50>50µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  membrane

Mechanism  Inhibits virus infection by interfering with six-helix bundle formation(fusion inhibitor).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C277H446N74O94

Absent amino acids  CMW

Common amino acids  LDN

Mass  6317.03

Pl  4.5

Basic residues  7

Acidic residues  11

Hydrophobic residues  19

Net charge  -4

Boman Index  -11645

Hydrophobicity  -54.82

Aliphatic Index  107.86

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  2980

Absorbance 280nm  54.18

Polar residues  16



Literature Information


Literature 1

Title   Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides.

Pubmed ID   15150417

Reference   Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8455-60.

Author   Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ.

DOI   10.1073/pnas.0400576101