To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01751
Peptide Name T21N17
Sequence RIQQIEQKIHHIEQRIQQIEQLLQLTVWGIKQLQARIL
Sequence Length 38
UniProt ID None
Source Synthetic construct
Activity Information
Target Organism HIV-1
Assay Cell-cell fusion assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target gp41
Mechanism function as potent inhibitors of viral infection by forming a coiled-coil structure covalently stabilized by interchain disulfide bonds
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C210H354N64O56
Absent amino acids CDFMNPSY
Common amino acids Q
Mass 4671.52
Pl 9.98
Basic residues 7
Acidic residues 3
Hydrophobic residues 16
Net charge 4
Boman Index -7050
Hydrophobicity -37.37
Aliphatic Index 143.68
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 148.65
Polar residues 2
Literature Information
Literature 1
Title Suitable fusion of N-terminal heptad repeats to achieve covalently stabilized potent N-peptide inhibitors of HIV-1 infection.
Pubmed ID 31932193
Reference Bioorg Med Chem. 2020 Feb 15;28(4):115214.
Author Lai W, Wang C, Yan J, Liu H, Zhang W, Lin B, Xi Z.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.