DRAVP ID  DRAVPe01759

Peptide Name   SARS-CoV-S (1149–1186)

Sequence  GDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELG

Sequence Length  38

UniProt ID  P59594 

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  SARS-CoV

Assay  Fusion inhibition assay

Activity 

• [Ref.15158473]SARS-CoV: inhibition of SARS-CoV cytopathic effect in Vero E6 cells ( synthetic HR2-38 IC50=0.5-5nM, GST-HR2-38 IC50=66.2nM)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  GST

Mechanism  as GST-fusion polypeptide

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.

Pubmed ID   15158473

Reference   Biochem Biophys Res Commun. 2004 Jun 18;319(1):283-8.

Author   Zhu J, Xiao G, Xu Y, Yuan F, Zheng C, Liu Y, Yan H, Cole DK, Bell JI, Rao Z, Tien P, Gao GF.

DOI   10.1016/j.bbrc.2004.04.141