DRAVP ID  DRAVPe01770

Peptide Name   Covid3

Sequence  LQTALYALMEEIHIAALEKTWTALRHQYT

Sequence Length  29

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  SARS-CoV-2

Assay  virus neutralization assay

Activity 

• [Ref.34624194]SARS-CoV-2:inhibition of infection in Vero cells(IC50=6.56 ± 2.14 μM);
• SARS-CoV-2 variants B.1.1.7:inhibition of infection in Vero cells(IC50=33.40 ± 10.75 μM);
• SARS-CoV-2 variants B.1.351:inhibition of infection in Vero cells(IC50=11.13 ± 3.82 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  The peptide acts as an inhibitor of the RBD–ACE2 interaction

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Acylation

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  D

Literature 1

Title   Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2.

Pubmed ID   34624194

Reference   J Med Chem. 2021 Oct 28;64(20):14955-14967.

Author   Valiente PA, Wen H, Nim S, Lee J, Kim HJ, Kim J, Perez-Riba A, Paudel YP, Hwang I, Kim KD, Kim S, Kim PM.

DOI   10.1021/acs.jmedchem.1c00655