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General Information
DRAVP ID DRAVPe01798
Peptide Name C6a
Sequence DWVRWI
Sequence Length 6
UniProt ID No entry found
Source Synthetic construct(derived from gp36 membrane proximal external region of FIV)
Activity Information
Target Organism FIV
Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target membrane
Mechanism Elicit antiviral activity by inhibiting the fusion of the FIV and host cell membrane.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C43H59N11O9
Absent amino acids ACEFGHKLMNPQSTY
Common amino acids W
Mass 874.01
Pl 5.84
Basic residues 1
Acidic residues 1
Hydrophobic residues 4
Net charge 0
Boman Index -1002
Hydrophobicity -18.33
Aliphatic Index 113.33
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 2200
Polar residues 0
Literature Information
Literature 1
Title Structural basis of antiviral activity of peptides from MPER of FIV gp36
Pubmed ID 30240422
Reference PLoS One. 2018 Sep 21;13(9):e0204042
Author Grimaldi M, Stillitano I, Amodio G, Santoro A, Buonocore M, Moltedo O, Remondelli P, D'Ursi AM.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.