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General Information
DRAVP ID DRAVPe01804
Peptide Name FBP2
Sequence RGAHIKGRWDSRCHRF
Sequence Length 16
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism Influenza A virus
Assay Plaque reduction assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target HA
Mechanism FBP could have dual functions: blocked HA-mediated fusion by binding and inhibited endosomal acidification from interfering viral entry by the endocytic pathway.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C85H132N34O20S
Absent amino acids ELMNPQTVY
Common amino acids R
Mass 1982.26
Pl 11.54
Basic residues 7
Acidic residues 1
Hydrophobic residues 4
Net charge 6
Boman Index -7147
Hydrophobicity -141.88
Aliphatic Index 30.63
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 366.67
Polar residues 4
Literature Information
Literature 1
Title Fusion-inhibition peptide broadly inhibits influenza virus and SARS-CoV-2, including Delta and Omicron variants.
Pubmed ID 35259078
Reference Emerg Microbes Infect. 2022 Dec;11(1):926-937.
Author Zhao H, Meng X, Peng Z, Lam H, Zhang C, Zhou X, Chan JF, Kao RYT, To KK, Yuen KY.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.