General Information


DRAVP ID  DRAVPe01806

Peptide Name   GI-20D

Sequence  gikefkrivqrikdflrnlv

Sequence Length  20

UniProt ID  No entry found

Source  Synthetic construct(derived from LL-37)



Activity Information


Target Organism  EBOV

Assay  Plaque assay

Activity 

  • [Ref.32252021]Ebola Virus(EBOV):inhibition of viral infection in Hela cells(IC50=0.99 µM);inhibition of viral infection in primary macrophages(IC50=2.2 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  Act as CatB inhibitors to block the endosomal processing of EBOV GP, thus preventing virus entry.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  D



Physicochemical Information


Formula  H-38O-19

Absent amino acids  ACDEFGHIKLMNPQRSTVWY

Common amino acids  ACDEFGHIKLMNPQRSTVWY

Mass  2473.01

Pl  11

Basic residues  0

Acidic residues  0

Hydrophobic residues  0

Net charge  0

Boman Index  0

Hydrophobicity  0

Aliphatic Index  0

Half Life 

  •     Mammalian:
  •     Yeast:
  •     E.coli:

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection.

Pubmed ID   32252021

Reference   iScience. 2020 Apr 24;23(4):100999.

Author   Yu Y, Cooper CL, Wang G, Morwitzer MJ, Kota K, Tran JP, Bradfute SB, Liu Y, Shao J, Zhang AK, Luo LG, Reid SP, Hinrichs SH, Su K.

DOI   10.1016/j.isci.2020.100999