To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01809
Peptide Name Kn2-7
Sequence FIKRIARLLRKIF
Sequence Length 13
UniProt ID No entry found
Source Synthetic construct(derived from BmKn2)
Activity Information
Target Organism HIV
Assay Luciferase Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism Kn2-7 aggregates and inserts into viral envelope so that the hydrophobic peptide region aligns with the lipid core region and the hydrophilic peptide regions form the interior region of the pore, with the help of positive charge of peptide somehow
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C81H140N24O14
Absent amino acids CDEGHMNPQSTVWY
Common amino acids IR
Mass 1674.15
Pl 12.31
Basic residues 5
Acidic residues 0
Hydrophobic residues 8
Net charge 5
Boman Index -2349
Hydrophobicity 55.38
Aliphatic Index 157.69
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Literature Information
Literature 1
Title Anti-HIV-1 activity of a new scorpion venom peptide derivative Kn2-7.
Pubmed ID 22536342
Reference PLoS One. 2012;7(4):e34947.
Author Chen Y, Cao L, Zhong M, Zhang Y, Han C, Li Q, Yang J, Zhou D, Shi W, He B, Liu F, Yu J, Sun Y, Cao Y, Li Y, Li W, Guo D, Cao Z, Yan H.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.