General Information

General Information

DRAVP ID DRAVPe01815

Peptide Name Hp1239

Sequence ILSYLWNGIKSIF

Sequence Length 13

UniProt ID P0DME8

Source Heterometrus petersii

Activity Information

Target Organism HSV-1

Assay Plaque forming assay

Activity

[Ref.24315793]Herpes simplex virus type 1(HSV-1):inhibition of viral inactivation in Vero cells(EC50=0.41 ± 0.06 μM);inhibition of viral attachment in Vero cells(EC50=5.73 ± 0.61 μM);inhibition of viral entry in Vero cells(EC50=4.32 ± 0.47 μM);inhibition of postentry in Vero cells(EC50=8.41 ± 0.73 μM).

Hemolytic Activity

[Ref.24315793]Human erythrocytes: HC50 = 33.32 ± 0.96 μM.

Cytotoxicity

[Ref.24315793]Vero cells: CC50 = 26.15 ± 1.91 μM.

Binding Target Not found

Mechanism inhibit HSV-1 when it attaches to the cell surface and when it has already bound to the cells but not entered yet and also exhibited potent inhibitory effects against viral particles proliferation in postentry stage.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C77H116N16O18

Absent amino acids ACDEHMPQRTV

Common amino acids I

Mass 1553.86

Pl 8.59

Basic residues 1

Acidic residues 0

Hydrophobic residues 7

Net charge 1

Boman Index 1172

Hydrophobicity 94.62

Aliphatic Index 150

Half Life

Mammalian:20 hour
Yeast:30 min
E.coli:>10 hour

Extinction Coefficient cystines 6990

Absorbance 280nm 582.5

Polar residues 5

Literature Information

Literature 1

Title Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1.

Pubmed ID 24315793

Reference Antiviral Res. 2014 Feb;102:1-10.

Author Hong W, Li T, Song Y, Zhang R, Zeng Z, Han S, Zhang X, Wu Y, Li W, Cao Z.

DOI 10.1016/j.antiviral.2013.11.013