General Information

General Information

DRAVP ID DRAVPe01816

Peptide Name Eval418

Sequence LWGEIWNTVKGLI

Sequence Length 13

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HSV-1

Assay Plaque reduction assay

Activity

[Ref.29290802]Herpes simplex virus type 1(HSV-1): inhibition of viral inactivation in Vero cells(IC50=2.48 µg/mL); inhibition of viral attachment in Vero cells(IC50=3.70 µg/mL); inhibition of viral entry in Vero cells(IC50=31.71 µg/mL).

Hemolytic Activity

[Ref.29290802]The hemolysis rate of human erythrocytes was less than 50% when the concentration of Eval418 was as high as 200 μg/mL.

Cytotoxicity

[Ref.29290802]Vero cells: CC50 = 68.50 µg/mL.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C74H113N17O18

Absent amino acids ACDFHMPQRSY

Common amino acids GILW

Mass 1528.81

Pl 6

Basic residues 1

Acidic residues 1

Hydrophobic residues 7

Net charge 0

Boman Index 869

Hydrophobicity 50.77

Aliphatic Index 142.31

Half Life

Mammalian:5.5 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 11000

Absorbance 280nm 916.67

Polar residues 4

Literature Information

Literature 1

Title Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1.

Pubmed ID 29290802

Reference Theranostics. 2018 Jan 1;8(1):199-211.

Author Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z.

DOI 10.7150/thno.21425