General Information

General Information

DRAVP ID DRAVPe01816

Peptide Name Eval418

Sequence LWGEIWNTVKGLI

Sequence Length 13

UniProt ID No entry found

Taxon ID None

Source Synthetic construct

Validation Experimentally Validated

Origin Information

Gene Name/ID Not Available

GenBank Not Available

Amino Acid position Not Available

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not available

Activity Information

Target Organism HSV-1

Assay Plaque reduction assay

Activity

[Ref.29290802]Herpes simplex virus type 1(HSV-1): inhibition of viral inactivation in Vero cells(IC50=2.48 µg/mL); inhibition of viral attachment in Vero cells(IC50=3.70 µg/mL); inhibition of viral entry in Vero cells(IC50=31.71 µg/mL).

Hemolytic Activity

[Ref.29290802]The hemolysis rate of human erythrocytes was less than 50% when the concentration of Eval418 was as high as 200 μg/mL.

Cytotoxicity

[Ref.29290802]Vero cells: CC50 = 68.50 µg/mL.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C74H113N17O18

Absent amino acids ACDFHMPQRSY

Common amino acids GILW

Mass 1528.81

Pl 6

Basic residues 1

Acidic residues 1

Hydrophobic residues 7

Net charge 0

Boman Index 869

Hydrophobicity 50.77

Aliphatic Index 142.31

Half Life

Mammalian:5.5 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 11000

Absorbance 280nm 916.67

Polar residues 4

Literature Information

Literature 1

Title Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1.

Pubmed ID 29290802

Reference Theranostics. 2018 Jan 1;8(1):199-211.

Author Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z.

DOI 10.7150/thno.21425