General Information

General Information

DRAVP ID DRAVPe01819

Peptide Name Eval418-FH4

Sequence LWHHIWNTVHHLI

Sequence Length 13

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HSV-1

Assay Plaque reduction assay

Activity

[Ref.29290802]Herpes simplex virus type 1(HSV-1): inhibition of viral inactivation in Vero cells(IC50=0.87 µg/mL); inhibition of viral attachment in Vero cells(IC50=0.63 µg/mL); inhibition of viral entry in Vero cells(IC50=4.37 µg/mL).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.29290802]Vero cells: CC50 = 27.58 µg/mL.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C83H116N24O16

Absent amino acids ACDEFGKMPQRSY

Common amino acids H

Mass 1705.99

Pl 7.1

Basic residues 4

Acidic residues 0

Hydrophobic residues 7

Net charge 4

Boman Index 53

Hydrophobicity 15.38

Aliphatic Index 142.31

Half Life

Mammalian:5.5 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 11000

Absorbance 280nm 916.67

Polar residues 2

Literature Information

Literature 1

Title Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1.

Pubmed ID 29290802

Reference Theranostics. 2018 Jan 1;8(1):199-211.

Author Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z.

DOI 10.7150/thno.21425