General Information


DRAVP ID  DRAVPe01819

Peptide Name   Eval418-FH4

Sequence  LWHHIWNTVHHLI

Sequence Length  13

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  HSV-1

Assay  Plaque reduction assay

Activity 

  • [Ref.29290802]Herpes simplex virus type 1(HSV-1): inhibition of viral inactivation in Vero cells(IC50=0.87 µg/mL); inhibition of viral attachment in Vero cells(IC50=0.63 µg/mL); inhibition of viral entry in Vero cells(IC50=4.37 µg/mL).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.29290802]Vero cells: CC50 = 27.58 µg/mL.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C83H116N24O16

Absent amino acids  ACDEFGKMPQRSY

Common amino acids  H

Mass  1705.99

Pl  7.1

Basic residues  4

Acidic residues  0

Hydrophobic residues  7

Net charge  4

Boman Index  53

Hydrophobicity  15.38

Aliphatic Index  142.31

Half Life 

  •     Mammalian:5.5 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  916.67

Polar residues  2



Literature Information


Literature 1

Title   Histidine-rich Modification of a Scorpion-derived Peptide Improves Bioavailability and Inhibitory Activity against HSV-1.

Pubmed ID   29290802

Reference   Theranostics. 2018 Jan 1;8(1):199-211.

Author   Zeng Z, Zhang R, Hong W, Cheng Y, Wang H, Lang Y, Ji Z, Wu Y, Li W, Xie Y, Cao Z.

DOI   10.7150/thno.21425