General Information


DRAVP ID  DRAVPe01823

Peptide Name   Figainin 2

Sequence  FLGAILKIGHALAKTVLPMVTNAFKPKQ

Sequence Length  28

UniProt ID  A0A2L2DDD0 

Source  Boana raniceps (Hypsiboas raniceps)



Activity Information


Target Organism  CHIKV,DENV,YFV

Assay  immunofluorescence assay

Activity 

  • [Ref.32443921]chikungunya virus (CHIKV):inhibition of viral infection in Huh7 cells(EC50=17 μM);
  • Dengue Serotype 4 Virus(DENV4):inhibition of viral infection in Huh7 cells(EC50=20.8 μM);
  • Yellow Fever viral (YFV):inhibition of viral infection in Huh7 cells(EC50=21.8 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref.32443921]No cytotoxicity against noninfected Huh7 cells at concentrations as high as 25 µM.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C142H236N36O33S

Absent amino acids  CDERSWY

Common amino acids  AKL

Mass  3007.72

Pl  10.48

Basic residues  5

Acidic residues  0

Hydrophobic residues  14

Net charge  5

Boman Index  1085

Hydrophobicity  57.5

Aliphatic Index  118.57

Half Life 

  •     Mammalian:1.1 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  5



Literature Information


Literature 1

Title   Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps.

Pubmed ID   32443921

Reference   Biomolecules. 2020 May 20;10(5):790.

Author   Santana CJC, Magalhães ACM, Prías-Márquez CA, Falico DA, Dos Santos Júnior ACM, Lima BD, Ricart CAO, de Pilger DRB, Bonotto RM, Moraes CB, Freitas-Júnior LH, Álvares ADCM, Freitas SM, Luz IS, Pires OR Jr, Fontes W, Castro MS.

DOI   10.3390/biom10050790