General Information

General Information

DRAVP ID DRAVPe01823

Peptide Name Figainin 2

Sequence FLGAILKIGHALAKTVLPMVTNAFKPKQ

Sequence Length 28

UniProt ID A0A2L2DDD0

Source Boana raniceps (Hypsiboas raniceps)

Activity Information

Target Organism CHIKV,DENV,YFV

Assay immunofluorescence assay

Activity

[Ref.32443921]chikungunya virus (CHIKV):inhibition of viral infection in Huh7 cells(EC50=17 μM);
Dengue Serotype 4 Virus(DENV4):inhibition of viral infection in Huh7 cells(EC50=20.8 μM);
Yellow Fever viral (YFV):inhibition of viral infection in Huh7 cells(EC50=21.8 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.32443921]No cytotoxicity against noninfected Huh7 cells at concentrations as high as 25 µM.

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C142H236N36O33S

Absent amino acids CDERSWY

Common amino acids AKL

Mass 3007.72

Pl 10.48

Basic residues 5

Acidic residues 0

Hydrophobic residues 14

Net charge 5

Boman Index 1085

Hydrophobicity 57.5

Aliphatic Index 118.57

Half Life

Mammalian:1.1 hour
Yeast:3 min
E.coli:2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Literature Information

Literature 1

Title Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog, Boana raniceps.

Pubmed ID 32443921

Reference Biomolecules. 2020 May 20;10(5):790.

Author Santana CJC, Magalhães ACM, Prías-Márquez CA, Falico DA, Dos Santos Júnior ACM, Lima BD, Ricart CAO, de Pilger DRB, Bonotto RM, Moraes CB, Freitas-Júnior LH, Álvares ADCM, Freitas SM, Luz IS, Pires OR Jr, Fontes W, Castro MS.

DOI 10.3390/biom10050790