General Information


DRAVP ID  DRAVPe01870

Peptide Name   FP3

Sequence  WLVFFVIFYFFRRRKK

Sequence Length  16

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  Influenza virus

Assay  Plaque reduction assay

Activity 

  • [Ref.22258859]influenza A virus A/WSN/33 H1N1:inhibition of viral replication in MDCK cells(IC50=0.00003 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  HA

Mechanism  the mechanism whereby FluPep mediates its antiviral effects is likely to involve inhibiting the binding of HA to sialic acid receptors or through interference with the fusion process by blocking protease cleavage.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C117H166N28O18

Absent amino acids  ACDEGHMNPQST

Common amino acids  F

Mass  2252.78

Pl  11.73

Basic residues  5

Acidic residues  0

Hydrophobic residues  10

Net charge  5

Boman Index  -2085

Hydrophobicity  45

Aliphatic Index  85

Half Life 

  •     Mammalian:2.8 hour
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  6990

Absorbance 280nm  466

Polar residues  1



Literature Information


Literature 1

Title   A novel family of peptides with potent activity against influenza A viruses.

Pubmed ID   22258859

Reference   J Gen Virol. 2012 May;93(Pt 5):980-986.

Author   Nicol MQ, Ligertwood Y, Bacon MN, Dutia BM, Nash AA.

DOI   10.1099/vir.0.038679-0