General Information

General Information

DRAVP ID DRAVPe01886

Peptide Name None

Sequence NGESSADWAKN

Sequence Length 11

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism Influenza A virus

Assay Hemagglutinin assay

Activity

[Ref.22595270]Influenza A virus (A/Roma-ISS/2/08 H1N1):inhibition of viral replication in MDCK cells(EC50=225±5.8 fM);
Influenza A virus (A/Parma/24/09 H1N1):inhibition of viral replication in MDCK cells(EC50=50±1.37 fM);
Influenza A virus (A/Parma/05/06 H3N2):inhibition of viral replication in MDCK cells(EC50=22.5±1.16 pM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref.22595270]MDCK cells:CC50>25 μM.

Binding Target HA

Mechanism The peptide may bind with HA and precent the attachment to target cells.

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C48H71N15O20

Absent amino acids CFHILMPQRTVY

Common amino acids ANS

Mass 1178.18

Pl 4.37

Basic residues 1

Acidic residues 2

Hydrophobic residues 3

Net charge -1

Boman Index -3427

Hydrophobicity -156.36

Aliphatic Index 18.18

Half Life

Mammalian:1.4 hour
Yeast:3 min
E.coli:>10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 550

Polar residues 5

Literature Information

Literature 1

Title Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus.

Pubmed ID 22595270

Reference Pathog Glob Health. 2012 Mar;106(1):12-9.

Author Ammendolia MG, Agamennone M, Pietrantoni A, Lannutti F, Siciliano RA, De Giulio B, Amici C, Superti F.

DOI 10.1179/2047773212Y.0000000004