General Information

General Information

DRAVP ID DRAVPe01899

Peptide Name SL174

Sequence GWAGWLLSPRGSRPSWGP

Sequence Length 18

UniProt ID No entry found

Source Synthetic construct

Activity Information

Target Organism HCV

Assay ELISA

Activity

[Ref.19264632]hepatitis C virus(J6/JFH1):inhibition of viral infection in Huh-7.5 cells(15% inhibition at 20 μM).

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target Not found

Mechanism No mechanism information found in the reference(s).

Structure Information

PDB ID None

Predicted Structure Download No predicted structure available

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C92H131N27O22

Absent amino acids CDEFHIKMNQTVY

Common amino acids G

Mass 1967.22

Pl 12

Basic residues 2

Acidic residues 0

Hydrophobic residues 6

Net charge 2

Boman Index -1764

Hydrophobicity -61.67

Aliphatic Index 48.89

Half Life

Mammalian:30 hour
Yeast:>20 hour
E.coli:>10 hour

Extinction Coefficient cystines 16500

Absorbance 280nm 970.59

Polar residues 7

Literature Information

Literature 1

Title Peptide inhibitors of hepatitis C virus core oligomerization and virus production.

Pubmed ID 19264632

Reference J Gen Virol. 2009 Jun;90(Pt 6):1319-1328.

Author Kota S, Coito C, Mousseau G, Lavergne JP, Strosberg AD.

DOI 10.1099/vir.0.008565-0