General Information


DRAVP ID  DRAVPe01905

Peptide Name   PB1 (111–130)

Sequence  MEVVQQTRMDKLTQGRQTYD

Sequence Length  21

UniProt ID  No entry found

Source  Synthetic construct



Activity Information


Target Organism  Influenza A virus

Assay  Hemagglutination assay

Activity 

  • [Ref.25446335]Influenza A virus(A/California/07/2009 (H1N1)pdm09/):antiviral activity of the peptide in MDCK cells(ED50=58 ± 2 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • No cytotoxicity information or data found in the reference(s) presented in this entry

Binding Target  Not found

Mechanism  The peptide may affect the early stages of the viral life cycle, which includes the synthesis of polymerase subunits and their subsequent assembly into functionally active complex. The peptide could interfere with these processes thus inhibiting virus replication.



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C100H165N31O34S2

Absent amino acids  ACFHINPSW

Common amino acids  Q

Mass  2427.73

Pl  5.88

Basic residues  3

Acidic residues  3

Hydrophobic residues  3

Net charge  0

Boman Index  -7101

Hydrophobicity  -120

Aliphatic Index  46.19

Half Life 

  •     Mammalian:30 hour
  •     Yeast:>20 hour
  •     E.coli:>10 hour

Extinction Coefficient cystines  1490

Absorbance 280nm  74.5

Polar residues  5



Literature Information


Literature 1

Title   Synthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments.

Pubmed ID   25446335

Reference   Antiviral Res. 2015 Jan;113:4-10.

Author   Matusevich OV, Egorov VV, Gluzdikov IA, Titov MI, Zarubaev VV, Shtro AA, Slita AV, Dukov MI, Shurygina AP, Smirnova TD, Kudryavtsev IV, Vasin AV, Kiselev OI.

DOI   10.1016/j.antiviral.2014.10.015