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General Information
DRAVP ID DRAVPe01908
Peptide Name PB1 (381–390)
Sequence FNESTRKKIE
Sequence Length 10
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism Influenza A virus
Assay Hemagglutination assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism The peptide may affect the early stages of the viral life cycle, which includes the synthesis of polymerase subunits and their subsequent assembly into functionally active complex. The peptide could interfere with these processes thus inhibiting virus replication.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C54H90N16O18
Absent amino acids ACDGHLMPQVWY
Common amino acids EK
Mass 1251.41
Pl 8.59
Basic residues 3
Acidic residues 2
Hydrophobic residues 2
Net charge 1
Boman Index -4435
Hydrophobicity -170
Aliphatic Index 39
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Literature Information
Literature 1
Title Synthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments.
Pubmed ID 25446335
Reference Antiviral Res. 2015 Jan;113:4-10.
Author Matusevich OV, Egorov VV, Gluzdikov IA, Titov MI, Zarubaev VV, Shtro AA, Slita AV, Dukov MI, Shurygina AP, Smirnova TD, Kudryavtsev IV, Vasin AV, Kiselev OI.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.