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General Information
DRAVP ID DRAVPe01913
Peptide Name PB1 (525–535)
Sequence IGVTVIKNNMI
Sequence Length 11
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism Influenza A virus
Assay Hemagglutination assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not found
Mechanism The peptide may affect the early stages of the viral life cycle, which includes the synthesis of polymerase subunits and their subsequent assembly into functionally active complex. The peptide could interfere with these processes thus inhibiting virus replication.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C53H96N14O15S
Absent amino acids ACDEFHLPQRSWY
Common amino acids I
Mass 1201.49
Pl 8.75
Basic residues 1
Acidic residues 0
Hydrophobic residues 5
Net charge 1
Boman Index 473
Hydrophobicity 107.27
Aliphatic Index 159.09
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Synthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments.
Pubmed ID 25446335
Reference Antiviral Res. 2015 Jan;113:4-10.
Author Matusevich OV, Egorov VV, Gluzdikov IA, Titov MI, Zarubaev VV, Shtro AA, Slita AV, Dukov MI, Shurygina AP, Smirnova TD, Kudryavtsev IV, Vasin AV, Kiselev OI.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.