DRAVP ID  DRAVPe01935

Peptide Name   TAT-Cd0

Sequence  GRKKRRQRRRC

Sequence Length  11

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Other Link  DRAVPa1018

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV-1

Assay  Antiviral assay

Activity 

• [Ref.21029018]Herpes simplex virus type 1(HSV-1):inhibition of viral infection in human corneal epithelial (HCE) cells(EC50=0.20 μM); exert antiviral activity by entry block(EC50=0.1 μM);exert antiviral activity by postentry(EC50~30.0 μM);exert antiviral activity by cell protection(EC50=0.4 μM);exert antiviral activity by virus inactivation(EC50=9.5 μM);exert antiviral activity by inhibitng attachment(EC50=3.0 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.21029018]human corneal epithelial (HCE) cells:CC50~100 μM.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   A cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells.

Pubmed ID   21029018

Reference   J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7.

Author   Larsen IV, Brandt CR.

DOI   10.1089/jop.2010.0076