DRAVP ID  DRAVPe01935

Peptide Name   TAT-Cd0

Sequence  GRKKRRQRRRC

Sequence Length  11

UniProt ID  No entry found

Source  Synthetic construct

Other Link  DRAVPa1018

Target Organism  HSV-1

Assay  Antiviral assay

Activity 

• [Ref.21029018]Herpes simplex virus type 1(HSV-1):inhibition of viral infection in human corneal epithelial (HCE) cells(EC50=0.20 μM); exert antiviral activity by entry block(EC50=0.1 μM);exert antiviral activity by postentry(EC50~30.0 μM);exert antiviral activity by cell protection(EC50=0.4 μM);exert antiviral activity by virus inactivation(EC50=9.5 μM);exert antiviral activity by inhibitng attachment(EC50=3.0 μM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.21029018]human corneal epithelial (HCE) cells:CC50~100 μM.

Binding Target  Not found

Mechanism  No mechanism information found in the reference(s).

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   A cationic TAT peptide inhibits Herpes simplex virus type 1 infection of human corneal epithelial cells.

Pubmed ID   21029018

Reference   J Ocul Pharmacol Ther. 2010 Dec;26(6):541-7.

Author   Larsen IV, Brandt CR.

DOI   10.1089/jop.2010.0076