To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe01953
Peptide Name Cmpd 11
Sequence KKR
Sequence Length 3
UniProt ID No entry found
Source Synthetic construct
Activity Information
Target Organism ZIKV
Assay Protease assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target NS2B-NS3 viral serine protease
Mechanism The peptide inhibits the NS2B-NS3 protease and thus inhibits virus replication.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Phenylacetyl
C-terminal Modification Amidation
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C18H38N8O4
Absent amino acids ACDEFGHILMNPQSTVWY
Common amino acids K
Mass 430.55
Pl 11.17
Basic residues 3
Acidic residues 0
Hydrophobic residues 0
Net charge 3
Boman Index -2602
Hydrophobicity -410
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Literature Information
Literature 1
Title SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease.
Pubmed ID 35123179
Reference Bioorg Med Chem. 2022 Mar 1;57:116631.
Author Colarusso S, Ferrigno F, Ponzi S, Pavone F, Conte I, Abate L, Beghetto E, Missineo A, Amaudrut J, Bresciani A, Paonessa G, Tomei L, Montalbetti C, Bianchi E, Toniatti C, Ontoria JM.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.