DRAVP ID  DRAVPe01956

Peptide Name   Dermaseptin-4

Sequence  ALWMTLLKKVLKAAAKAALNAVLVGANA

Sequence Length  28

UniProt ID  P80280 

Taxon ID  None

Source  Phyllomedusa sauvagii

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV

Assay  Chemiluminescence Reporter Gene Assay

Activity 

• [Ref.15780876]human immunodeficiency virus type 1 (HIV-1):Inhibition of viral infection in Vero P4-CCR5 cells(IC50=2 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.15780876]P4-CCR5 cells:CC50=5.6 μM.

Binding Target  viral membrane

Mechanism  exerts a selective activity on viral particles and disturbs their organization by breaking the viral membrane, leading to the exposure of HIV-1 core and its dissociation. 

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro. 

Pubmed ID   15780876

Reference   Virology. 2005 Apr 10;334(2):264-75. 

Author   Lorin C, Saidi H, Belaid A, Zairi A, Baleux F, Hocini H, Bélec L, Hani K, Tangy F.

DOI   10.1016/j.virol.2005.02.002