DRAVP ID  DRAVPe01956

Peptide Name   Dermaseptin-4

Sequence  ALWMTLLKKVLKAAAKAALNAVLVGANA

Sequence Length  28

UniProt ID  P80280 

Source  Phyllomedusa sauvagii

Target Organism  HIV

Assay  Chemiluminescence Reporter Gene Assay

Activity 

• [Ref.15780876]human immunodeficiency virus type 1 (HIV-1):Inhibition of viral infection in Vero P4-CCR5 cells(IC50=2 µM).

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref.15780876]P4-CCR5 cells:CC50=5.6 μM.

Binding Target  viral membrane

Mechanism  exerts a selective activity on viral particles and disturbs their organization by breaking the viral membrane, leading to the exposure of HIV-1 core and its dissociation. 

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro. 

Pubmed ID   15780876

Reference   Virology. 2005 Apr 10;334(2):264-75. 

Author   Lorin C, Saidi H, Belaid A, Zairi A, Baleux F, Hocini H, Bélec L, Hani K, Tangy F.

DOI   10.1016/j.virol.2005.02.002